The Pangas Lab at Baylor College of Medicine studies the genetic foundations of male and female infertility to address the growing infertility crisis that affects 1 in 6 couples worldwide, according to the World Health Organization. Infertility poses significant medical, economic, and social challenges, making reproductive research essential for ensuring that individuals and families have the opportunity to build the futures they envision.
Since 2007, our mission has been to uncover the basic biological mechanisms that drive mammalian reproduction, laying the groundwork for medical advances that improve public health, expand reproductive options, and reduce the long-term burden of infertility on families and the healthcare system.
We use cutting-edge genetic models, including CRISPR/Cas9 and Cre-loxP, to identify genes essential for ovarian and uterine function. Our research has revealed key causes of primary ovarian insufficiency, infertility, polycystic ovary syndrome, and ovarian cancer, which impact fertility and contribute to economic, medical, and psychological burdens.
In addition to the key genetic models, we work with patient samples from individuals with reproductive disorders and those undergoing assisted reproduction. By integrating omic profiling, mutation analysis, and PDX models, we bridge scientific discovery with clinical application, advancing fertility research to improve outcomes for all.
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Applicants interested in graduate studies at Baylor College of Medicine, should visit the website at https://www.bcm.edu/education/schools/graduate-school-of-biomedical-sciences
Interested in Reproductive Biology Research at Baylor College of Medicine? Please visit the Center for Reproductive Biology https://www.bcm.edu/research/centers/reproductive-medicine
Want to join our NIH T32 as a postdoctoral candidate? Please click on the T32 Tab!
Science as a Career
Somewhere, something incredible is waiting to be known.
Carl Sagan
Nothing in life is to be feared, it is only to be understood.
Marie Curie, Nobel Laureate 1903, 1911
The important thing is not to stop questioning. Curiosity has its own reason for existing.
Albert Einstein
Pangas Laboratory 